3-Nitrobenzaldehyde → HCID 86749798, compound

Participants

Reaction Steps

A solution of n-butyl acetoacetate (0.10 mole), methyl 3-aminocrotonate (0.10 mole), 3-nitrobenzaldehyde (0.10 mole) and 150 mL of i-PrOH was refluxed overnight (18 h). The volatiles were removed in vacuo and the residue purified by flash chromatography (SiO2 : EtOAc/Hex) to furnish the product in 49% yield as low melting, yellow solid: mp 69°-70° C. Anal. Calcd for C20H24N2O6 : C, 61.85; H, 6.23; N, 7.21. Found: C, 62.02; H, 6.21; N, 6.95.

Provenance & Evidence