HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Aminoethyl)-5-(benzoxazol-2-yl)-2-methylbenzimidazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-(Benzoxazol-2-yl)-1-(2-(tert-butoxycarbonylamino)ethyl)-2-methylbenzimidazole | HCID 67498579 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(2-Aminoethyl)-5-(benzoxazol-2-yl)-2-methylbenzimidazole hydrochloride | HCID 67497703 | — |
Reaction Steps
5-(Benzoxazol-2-yl)-1-(2-(tert-butoxycarbonylamino)ethyl)-2-methylbenzimidazole (see Working Example 55-2) (100 mg, 0.255 mmol) was added to a 4N hydrochloric acid solution in dioxane (10 mL), and this was heated to reflux for 5 hours. After the reaction was complete, this was concentrated to dryness to yield the title compound (95 mg, quant.) as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829035B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-425ada4b150b40c0977927b116c48c29 |
| Source note | uspto-grants-2014_09 |