HCID 21473739, compound → HCID 10107954, compound

HRID 742301Notes

Reaction equation

HRID 742301 reaction equation
[CH2:1]([O:3][C:4](/[CH:6]=[CH:7]/[C:8]1[S:12][C:11]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[CH:10][CH:9]=1)=[O:5])[CH3:2]>C(O)C.[C].[Pd]>[CH2:1]([O:3][C:4]([CH2:6][CH2:7][C:8]1[S:12][C:11]([C:13]([O:15][C:16]([CH3:17])([CH3:19])[CH3:18])=[O:14])=[CH:10][CH:9]=1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 21473739HCID 21473739, compound

Product 1

HCID 10107954HCID 10107954, compoundYield 99.7%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The t-butyl 5-(2-ethoxycarbonyl-E-ethenyl)-2-thiophenecarboxylate (7.58 g, 26.8 mmol) prepared in the Preparative Example 14 was catalytically reduced with 10% palladium-carbon (1.05 g) in ethanol at room temperature. After the completion of the reaction, the catalyst was filtered out and the filtrate was concentrated and evaporated to dryness in a vacuum. 7.6 g of the title compound was obtained.

Workup

  1. customAfter the completion of the reaction
  2. filtrationthe catalyst was filtered out
  3. concentrationthe filtrate was concentrated
  4. customevaporated to dryness in a vacuum

Sources & evidence

ORD record
ord-c766c541f0c84f15a9a7c60cc344d910
Source dataset
uspto-grants-1996_09
Patent number
US05554615

Reaction notes

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