4-Aminobiphenyl → N-Acetyl-4-aminobiphenyl

HRID 742333Notes

Reaction equation

HRID 742333 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C1(C)C=CC=CC=1>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1)[C:14]([CH3:15])=[O:16]

Participants

4

Reactant 2

HCID 71024-AminobiphenylHCID 7918Acetic Anhydride

Product 1

HCID 19998N-Acetyl-4-aminobiphenylYield 99.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

4-Aminobiphenyl (15 g, 88.76 mmol)in toluene (250 ml) was added acetic anhydride (8.5 ml, 90 mmol). The mixture was stirred at ambient temperature for 1 hour. Following the reaction the mixture was poured into petroleum ether (500 ml), the product was filtered off, washed with petroleum ether and dried to yield 4-acetaminobiphenyl (18.7 g).

Workup

  1. customthe reaction the mixture
  2. filtrationthe product was filtered off
  3. washwashed with petroleum ether
  4. customdried

Sources & evidence

ORD record
ord-de87aa46c58840a5b68040f0ff17e3d3
Source dataset
uspto-grants-1996_09
Patent number
US05554630

Reaction notes

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