Potassium Hydroxide → HCID 19049366, compound

Participants

Reaction Steps

To a solution of 1-((3,5-bis (trifiuoromethyl)phenyl)methyloxy)-2-(N-((carbomethoxy) methyl)amino)-3,3-diphenylpropane (Example 1g, 2.38 g) in tetrahydrofuran (25 ml) was added 1M-potassium hydroxide solution (25 ml) and the mixture heated to reflux for 16 hours. The solvent was removed by evaporation and 1M-hydrochloric acid was added to an aqueous solution of the residue until pH=2. The gum which formed was recrystallised from aqueous ethanol to give N-(1-((3,5-bis(trifiuoromethyl) phenyl)methyloxy)-3,3- diphenylprop-2-yl)glycine mp 116°-119° C.; m/e (CI+) 512 (M+H), (CI-) 511 (M). Found: C, 60.06; H, 4.55; N, 2.66; C26H23NO3F6.0.5(H2O) requires C, 60.00; H, 4.64; N, 2.69%.

Provenance & Evidence