Hydrochloric Acid → HCID 19426274, compound

Participants

Reaction Steps

A solution of 1-{3-[2,2-dimethyl-4-aminomethyl-1,3-dioxolanyl]-propyl}-4,7-bis-(carboxymethyl)-1,4,7-triazacyclononane (12.4 g, 0.03 mol) in 100 mL of deionized water is adjusted to pH 10 with 1N sodium hydroxide. Then bromoacetic acid (4.2 g, 0.03 mol) is added and the mixture is heated to 50 C. for 15 hours, keeping the pH of the solution between 9 and 10. Then the pH is adjusted to 4 with 1N hydrochloric acid and the solvent is evaporated under reduced pressure to give 1-[3-[N-(2,3-dihydroxypropyl)-N-(carboxymethyl)-amino]propyl]-4,7-bis-(carboxymethyl)-1,4,7-triazacyclononane.

Provenance & Evidence