Gadolinium oxide (2/3) → Hexahydro-1H-1,4,7-triazonine-1,4(5H)-diacetic acid

HRID 742534Notes

Reaction equation

HRID 742534 reaction equation
OC(CO)CN(CCC[N:12]1[CH2:20][CH2:19][N:18]([CH2:21][C:22]([OH:24])=[O:23])[CH2:17][CH2:16][N:15]([CH2:25][C:26]([OH:28])=[O:27])[CH2:14][CH2:13]1)CC(O)=O.[O-2].[Gd+3].[O-2].[O-2].[Gd+3]>O>[C:22]([CH2:21][N:18]1[CH2:17][CH2:16][N:15]([CH2:25][C:26]([OH:28])=[O:27])[CH2:14][CH2:13][NH:12][CH2:20][CH2:19]1)([OH:24])=[O:23]

Participants

4

Reactant 2

HCID 159427Gadolinium oxide (2/3)HCID 19426274HCID 19426274, compound

Product 1

HCID 393901Hexahydro-1H-1,4,7-triazonine-1,4(5H)-diacetic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 1-[3-[N-(2,3-dihydroxypropyl)-N-(carboxymethyl)amino]propyl]4,7-bis(carboxymethyl)-1,4,7-triazacyclononane (5.0 g, 0.010 mol) in 50 mL of deionized water is added gadolinium oxide (1.8 g, 0.005 mol). The slurry is heated at 80 C. under argon atmosphere for 15 hours. The resulting solution is cooled at 25 C., filtered and the filtrate is evaporated under reduced pressure to give 1-[3-[N-2,3-dihydroxypropyl)-N-(carboxymethyl)amino]propyl]-4,7-bis-(carboxymethyl)-1,4,7-triazacyclononane, gadolinium(III) complex.

Workup

  1. temperatureThe slurry is heated at 80 C
  2. temperatureThe resulting solution is cooled at 25 C
  3. filtration, filtered
  4. customthe filtrate is evaporated under reduced pressure

Sources & evidence

ORD record
ord-3f55eef554774a238d61d78d0a02d8c9
Source dataset
uspto-grants-1996_09
Patent number
US05554749

Reaction notes

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