Hydrochloric Acid → HCID 19426276, compound

Participants

Reaction Steps

A solution of 1-(2-piperazinoethyl)-4,7-bis-(carboxymethyl)-1,4,7-triazacyclononane (10.7 g, 0.03 mol) in 100 mL of deionized water is adjusted to pH 10 with 1N sodium hydroxide solution. Then bromoacetic acid (4.2 g, 0.03 mol) is added and the solution is heated at 50 C. for 15 hours, keeping the pH between 9 and 10 with 1N sodium hydroxide. After cooling the reaction mixture to 25 C., the pH is adjusted to 4 with 1N hydrochloric acid. The solvent is removed under reduced pressure to give 1-[2-(4-carboxymethylpiperazino)ethyl]-4,7-bis-(carboxymethyl)-1,4,7-triazacyclonane.

Provenance & Evidence