反应详情

Ethyl 4-amino-4-(3-methoxyphenyl)butanoate (9.39 g) was dissolved in toluene (50 ml) and the solution heated under reflux for 0.5 hr to 1.0 hr. The mixture was cooled to ambient temperature, the precipitate was collected, and the filtrate was concentrated. The residue was recrystallized from ether to give 6.80 g (90%) of product, mp 84°-85° C.

1. temperaturethe solution heated
2. temperatureunder reflux for 0.5 hr to 1.0 hr
3. customthe precipitate was collected
4. concentrationthe filtrate was concentrated
5. customThe residue was recrystallized from ether