反应详情

To a solution of 2-{2-[2-(3-methoxyphenyl)-1-pyrrolidinyl]ethyl}-1H-isoindole-1,3(2H)dione (0.92 g) in ethanol (30 ml) and chloroform (5 ml) was added anhydrous hydrazine (98%, 0.42 ml) at ambient temperature, under nitrogen. The reaction mixture was warmed under reflux for 1.5 hrs, cooled to ambient temperature, and filtered. The filter cake was washed with ethanol and the combined filtrates were concentrated. The residue was diluted with dichloromethane/ether. The organic solvents were decanted and concentrated to give N-(2-aminoethyl)-2-(3-methoxyphenyl)pyrrolidine.

1. temperatureThe reaction mixture was warmed
2. temperatureunder reflux for 1.5 hrs
3. filtrationfiltered
4. washThe filter cake was washed with ethanol
5. concentrationthe combined filtrates were concentrated
6. additionThe residue was diluted with dichloromethane/ether
7. customThe organic solvents were decanted
8. concentrationconcentrated