Octyl isocyanate → 3-[1-Phenylmethyl-2-pyrrolidinyl]phenyl octylcarbamate

HRID 742598Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 742598
[C:1]1([CH2:7][N:8]2[CH2:12][CH2:11][CH2:10][CH:9]2[C:13]2[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:20]([N:28]=[C:29]=[O:30])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]>O1CCCC1>[CH2:20]([NH:28][C:29](=[O:30])[O:19][C:15]1[CH:16]=[CH:17][CH:18]=[C:13]([CH:9]2[CH2:10][CH2:11][CH2:12][N:8]2[CH2:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH:14]=1)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH3:27]

Komponenten

4

Edukt 2

HCID 76616Octyl isocyanateHCID 233612863-(1-Phenylmethyl-2-pyrrolidinyl)phenol

Produkt 1

HCID 152913763-[1-Phenylmethyl-2-pyrrolidinyl]phenyl octylcarbamateAusbeute 52 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of 3-(1-phenylmethyl-2-pyrrolidinyl)phenol (0.06 g) in dry tetrahydrofuran (30 ml) was added octyl isocyanate (0.44 ml) at ambient temperature, under nitrogen. The reaction mixture was stirred for 17 hrs and filtered through a pad of celite. The filter cake was washed with ethyl acetate and the combined filtrates were concentrated. The residue was purified by flash column chromatography (silica gel, dichloromethane). The appropriate fractions were collected and concentrated to give 0.50 g (52%) of product. The analytical sample was prepared by flushing the product through alumina with ether.

Aufarbeitung

  1. filtrationfiltered through a pad of celite
  2. washThe filter cake was washed with ethyl acetate
  3. concentrationthe combined filtrates were concentrated
  4. customThe residue was purified by flash column chromatography (silica gel, dichloromethane)
  5. customThe appropriate fractions were collected
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b10cff5d52ec49709b4e3e34374aefb0
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05554750

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