Ethanol → Ethyl (3-Hydroxyphenyl)acetate

HRID 742632Notes

Reaction equation

HRID 742632 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.[CH2:12](O)[CH3:13]>OS(O)(=O)=O>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 121223'-Hydroxyphenylacetic acid

Product 1

HCID 572437Ethyl (3-Hydroxyphenyl)acetate

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

A solution of 55 g of 3-hydroxyphenylacetic acid in 400 ml of 100° ethanol is refluxed overnight in the presence of a few drops of concentrated H2SO4. It is evaporated to dryness and the residue is taken up in ethyl ether and washed with water and then with a saturated aqueous solution of NaHCO3. After drying over MgSO4 followed by evaporation, 58 g of an oil are obtained.

Workup

  1. customIt is evaporated to dryness
  2. washwashed with water
  3. dry with materialAfter drying over MgSO4
  4. customfollowed by evaporation, 58 g of an oil
  5. customare obtained

Sources & evidence

ORD record
ord-f369d2ee1c8c4697a028c706df1c184f
Source dataset
uspto-grants-1996_09
Patent number
US05554763

Reaction notes

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