HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(3-isopropoxyphenylacetyl)-N-(2-methoxyethyl)-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 2-(3-(Propan-2-yloxy)phenyl)acetic acid | HCID 16638924 | — |
| Reactant | N-(2-methoxyethyl)-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamine | HCID 19705336 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(3-isopropoxyphenylacetyl)-N-(2-methoxyethyl)-2-(3,4-dichlorophenyl)-4-(tetrahydropyran-2-yloxy)butylamine | HCID 19705328 | 80.6% |
Reaction Steps
2.6 g of BOP are added to a solution cooled at 0° C. of 1.9 g of the product prepared in step 2, 1.2 g of triethylamine and 0.96 g of 3-isopropoxyphenylacetic acid in 50 ml of CH2Cl2. The reaction mixture is stirred for one hour and is then concentrated under vacuum. The residue is taken up in ethyl acetate, washed with water, dried over Na2SO4 and concentrated under vacuum. 2.2 g of the expected product is obtained, which is directly used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05554763 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-f7c32892a3fe4a978366814dc08f965b |
| Source note | uspto-grants-1996_09 |