反应详情

To a methanol (5 mL) solution of 2-(2-(1,2,3,4-tetrahydronaphthalen-1-yl)aminoanilin-5-yl)benzoxazole (see Working Example 87-1) (0.30 g, 0.8 mmol) was added methyl acetimidate hydrochloride (0.10 g, 0.9 mmol), and this was heated to reflux for 3 hours. After the reaction solution was cooled, water was added, and this was extracted with chloroform. After the organic layer obtained was dried over anhydrous sodium sulfate, it was filtered and concentrated. The residue obtained was purified by silica gel column chromatography to yield the title compound (0.15 g, 47% yield) as a colorless amorphous mass.

1. temperaturethis was heated
2. temperatureto reflux for 3 hours
3. temperatureAfter the reaction solution was cooled
4. extractionthis was extracted with chloroform
5. customAfter the organic layer obtained
6. dry with materialwas dried over anhydrous sodium sulfate, it
7. filtrationwas filtered
8. concentrationconcentrated
9. customThe residue obtained
10. customwas purified by silica gel column chromatography