Tetrahydrofuran → 2-(2-(3-(Morpholin-4-yl)-n-propyl)aminoanilin-4-yl)benzoxazole

Participants

Reaction Steps

To a solution of 2-(N-(2-(morpholin-4-yl)-n-propyl)-2-nitroanilin-4-yl)benzoxazole (see Working Example 96-1) (665 mg, 1.74 mmol) in tetrahydrofuran (10 mL) was added 10% palladium-carbon (70 mg). A hydrogen atmosphere was then substituted in the flask, and this was stirred at room temperature for 17 hours. After the reaction was finished, this was filtered through Celite, and the filtrate was concentrated to yield the title compound (605 mg, 99% yield).

Provenance & Evidence