反应详情

Water (6 ml) and sulfuric acid (3.6 g) were added to 2.0 g (7.11 mmol) of 4,4-dimethyl-2-(4'-hydroxymethylbiphenyl-2-yl)oxazoline, followed by heating under reflux for 30 hours. After the reaction liquid was cooled, it was neutralized with a 10% aqueous solution of sodium hydroxide and extracted with chloroform. After the organic phase was washed with water and dried, it was subjected to vacuum concentration. The residue was purified by silica gel column chromatography (a chloroform/methanol system) to give 1.05 g of the title compound (yield 65%).

1. temperatureby heating
2. temperatureunder reflux for 30 hours
3. customAfter the reaction liquid
4. temperaturewas cooled
5. extractionextracted with chloroform
6. washAfter the organic phase was washed with water
7. customdried
8. concentrationit was subjected to vacuum concentration
9. customThe residue was purified by silica gel column chromatography (a chloroform/methanol system)