Methanol → (2S,3S,4S,5S)-2,5-Bis-(N-(N-((N-methyl-N-((2-amino-4-thiazolyl)methyl)amino)carbonyl)valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	(2S,3S,4S,5S)-2,5-Bis-(N-(N-((N-methyl-N-((2-((((t-butyl)oxy)carbonyl)amino)-4-thiazolyl)methyl)amino)carbonyl)valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane	HCID 18655521	—
Solvent	Chloroform	HCID 6212	—
Product	(2S,3S,4S,5S)-2,5-Bis-(N-(N-((N-methyl-N-((2-amino-4-thiazolyl)methyl)amino)carbonyl)valinyl)amino)-3,4-dihydroxy-1,6-diphenylhexane	HCID 18655519	—

Reaction Steps

Using the procedure of Example 58B but replacing the resultant compound of Example 58A with the resultant compound of Example 92 provided, after silica gel chromatography using first 5% then 10% methanol in chloroform, 62 mg (43%) of the desired compound (Rf 0.16, 10% methanol in chloroform) as an off-white solid, m.p. 122°-124° C. Mass spectrum: (M+1)+ =837.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05554783
Source dataset	uspto-grants-1996_09
ORD ID	ord-cf4e049cc24344978f54f518c5b77785
Source note	uspto-grants-1996_09