Ethanol → HCID 12421492, compound

Participants

Reaction Steps

A solution of 25 g 3-cyano-l-ethyl-1,4-dihydro-4-oxocinnoline, 100 g sodium hydroxide, 400 ml ethanol and 100 ml water was stirred at 70° C. for 3 hr. After the removal of ethanol by evaporation, to the mixture was added conc. hydrochloric acid to precipitate crystalline materials. Precipitates were separated by filtration, washed with water, ethyl ether/ethanol and dried to yield 25.6 g of the desired compound. Mp.=206°-208° C. 1H-NMR(DMSO-d6, δ ppm) 1.48 (3H,t), 4.76 (2H,q), 7.76 (1H,t), 8.07 (1H,m), 8.19 (1H,d), 8.33 (1H,d)

Provenance & Evidence