Acetic Anhydride → HCID 19027726, compound

Participants

Reaction Steps

1-{3-[4-(3-aminophenyl)-1-piperazinyl]propyl}-5-chloro-3,4-dihydrocarbostyril (1 g) was dissolved in 10 ml of chloroform, 5 ml of acetic anhydride and 0.1 g of 4-dimethylaminopyridine were added, and the mixture was heated under reflux for 30 minutes. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography and then converted to the hydrochloride form, which was recrystallized from ethanol to give 900 mg of 1-{3-[4-(3-acetylaminophenyl)-1-piperazinyl]propyl}-5-chloro-3,4-dihydrocarbostyril hydrochloride as colorless needles.

Provenance & Evidence