反应详情

To 2-(2-(4-methoxycarbonylphenylmethyl)aminonitrobenzen-5-yl)benzoxazole (see Working Example 113-2) (367 mg, 0.910 mmol) was added iron powder (102 mg, 1.82 mmol), 10% aqueous acetic acid (5 mL) and methanol (7 mL), and this was heated to reflux for 16 hours. After the reaction solution was cooled, saturated aqueous sodium hydrogen carbonate solution and chloroform were added, this was filtered through Celite, and the filtrate obtained was extracted. After the organic layer obtained was dried over anhydrous sodium sulfate, it was filtered and concentrated. The residue obtained was purified by silica gel column chromatography to yield the title compound (61.8 mg, 18% yield).

1. temperaturethis was heated
2. temperatureto reflux for 16 hours
3. temperatureAfter the reaction solution was cooled
4. filtrationthis was filtered through Celite
5. customthe filtrate obtained
6. extractionwas extracted
7. customAfter the organic layer obtained
8. dry with materialwas dried over anhydrous sodium sulfate, it
9. filtrationwas filtered
10. concentrationconcentrated
11. customThe residue obtained
12. customwas purified by silica gel column chromatography