L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]- → HCID 22865438, compound

Participants

Reaction Steps

In substantially the same manner as in Example 5, N-tosyl-1,4-diaminobutane (1.27 g) was condensed with Boc-L-Phe-OH (1.47 g) to give N-(Boc-L-phenylalanyl)-N'-tosyl-1,4-diaminobutane (2.19 g) (yield 85%). After Boc group elimination with TFA, the product was condensed with (2S,3S)-ethyl hydrogen trans-epoxysuccinate (774 mg) as obtained in Reference Example 8 to yield the title compound (compound 32; 1.55 g) [yield 67%].

Provenance & Evidence