Morpholine → HCID 22865482, compound

Participants

Reaction Steps

In substantially the same manner as in Example 5, morpholine (1.41 ml) and Boc-L-Tyr(Bzl)-OH (6.00 g, manufactured by Peptide Institute, Inc.) were condensed to give N-(O-benzyl-Boc-L-tyrosyl)morpholine (8.10 g) as a white powder (yield quantitative). After Boc group elimination with TFA, the product was condensed with (2S,3S)-ethyl hydrogen trans-epoxysuccinate (2.76 g) as obtained in Reference Example 8 to yield the title compound (compound 58; 6.14 g) as a white powder (yield 81%).

Provenance & Evidence