Morpholine → HCID 22865437, compound

Participants

Reaction Steps

In substantially the same manner as in Example 5, morpholine (280 μl) was condensed with Boc-L-homophenylalanine (900 mg, manufactured by Bachem Fein Chemikalien AG, Switzerland) to give N-(BOC-L-homophenylalanyl)morpholine (1.06 g) as a white powder (yield 95%). After Boc group elimination with 4N HCl/ethyl acetate, the product was condensed with (2S,3S)-ethyl hydrogen trans-epoxysuccinate (338 mg) as obtained in Reference Example 8 to yield the title compound (compound 65; 630 mg) as a white powder (yield 77%).

Provenance & Evidence