Morpholine → HCID 22865431, compound

Participants

Reaction Steps

In substantially the same manner as in Example 5, morpholine (275 μl) was condensed with Boc-3-(1-naphthyl)-L-alanine (970 mg, manufactured by Bachem Fein Chemikalien AG, Switzerland) to give N-[Boc-3-(1-naphthyl)-L-alanyl]morpholine (1.18 g) as a white powder (yield quantitative). After Boc group elimination with TFA, the product was condensed with (2S,3S)-ethyl hydrogen trans-epoxysuccinate (620 mg) as obtained in Reference Example 8 to yield the title compound (compound 79; 1.09 g) as a white powder (yield 75%).

Provenance & Evidence