Sodium Bicarbonate → 5-(Benzoxazol-2-yl)-1-(4-methoxycarbonylphenylmethyl)-2-methylbenzimidazole

関与物質

反応手順

To a solution of 2-(2-(4-methoxycarbonylphenylmethyl)aminoanilin-5-yl)benzoxazole (see Working Example 113-2) (59.0 mg, 0.159 mmol) in methanol (3 mL) was added methyl acetimidate hydrochloride (19 mg, 0.174 mmol), and this was heated to reflux for 1.5 hours. After the reaction was complete, saturated aqueous sodium hydrogen carbonate solution was added, and this was stirred for several minutes at room temperature. The crystals obtained were filtered, and after being washed with water, they were dried to yield the title compound (62.2 mg, 98% yield) as yellow crystals.

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