Morpholine → N-[Boc-3-(2-naphthyl)-L-alanyl]morpholine

Participants

Reaction Steps

In substantially the same manner as in Example 5, morpholine (275 μl) was condensed with Boc-3-(2-naphthyl)-L-alanine (900 mg, manufactured by Bachem Fein Chemikalien AG, Switzerland) to give N-[Boc-3-(2-naphthyl)-L-alanyl]morpholine (1.10 g) as a white powder (yield quantitative). After Boc group elimination with trifluoroacetic acid, the product was condensed with (2S,3S)-ethyl hydrogen trans-epoxysuccinate as obtained in Reference Example 8 (312 mg) to yield the title compound (compound 81; 695 mg) as a white powder (yield 84%).

Provenance & Evidence