HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 23698895, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Ethyl 2-hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoate | HCID 19423387 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 23698895 | HCID 23698895 | 54.4% |
Reaction Steps
Ethyl 2-hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoate (15.5g, 35 mmol) was refluxed in potassium hydroxide (10 g, 0.15 mol) in water (100 ml) for 1 h. After cooling to ca 70° C. ethyl acetate (50 ml) was added and hydrochloric acid was added to reach pH 7-8. Cooling with stirring and then filtration gave directly 8.5 g of the product (51%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05556855 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-9a5b786293144a929709828fa8447c3e |
| Source note | uspto-grants-1996_09 |