Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Acetylsalicylic acid → 2-Hydroxy-5-[1-oxo-3-[4-[(2-pyridinylamino)sulfonyl]phenyl]-2-propenyl]benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Acetylsalicylic acid | HCID 83151 | — |
| 반응물 | 4-Formyl-N-(2-pyridinyl)benzenesulfonamide | HCID 19423393 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sodium Hydroxide | HCID 14798 | — |
| 생성물 | 2-Hydroxy-5-[1-oxo-3-[4-[(2-pyridinylamino)sulfonyl]phenyl]-2-propenyl]benzoic acid | HCID 54287379 | — |
반응 단계
4-Formyl-N-(2-pyridinyl)benzenesulfonamide (5.7 g, 0.022 mol), 5-acetyl-2-hydroxybenzoic acid (6.64 g, 0.044 mol) in 5M sodium hydroxide (20 ml) were stirred for 3 days at room temperature. The solution was diluted with water (100 ml) and acetic acid added dropwise in excess. The precipitate was collected by filtration and washed with water. After drying, the material was recrystallized from acetic acid and dried at 120° C. in vacuo. Yield 6.4 g, 66%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05556855 |
| 출처 데이터셋 | uspto-grants-1996_09 |
| ORD ID | ord-d2b7b32d120e4b5c8f212fbdda865c4e |
| 출처 메모 | uspto-grants-1996_09 |