Ethyl bromoacetate → HCID 19423555, compound

Participants

Reaction Steps

To a solution of 1.5 g (4.88 mmol) of 3-(piperidin-4-yl)-4-phenyl-3,4-dihydro-2(1H)-quinazolinone in 30 mL of isopropanol were added 896 mg (5.37 mmol) of ethyl bromoacetate, 853 mg (96.18 mmol) of potassium carbonate and 20 mg of potassium iodide, and the mixture was heated under reflux for 3 hours. The hot solution was subjected to filtration, and the solid matter was washed with 200 mL of hot isopropanol. The filtrate was concentrated in vacuo, and the residue was purified by means of column chromatography (silica gel, 1:9 :90 aqueous ammonia:methanol:chloroform) to give 1.88 g (4.37 mmol) of the title compound.

Provenance & Evidence