Stannous chloride dihydrate → HCID 19423607, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 540 mg (1.22 mmol) of 3-[1-(3-nitrobenzyl)piperidin-4-yl]-4-phenyl-3,4-dihydro-2(1H)quinazolinone in 50 mL of ethanol was added 826 mg (3.66 mmol) of SnCl2.2H2O, and the mixture was stirred for 12 hours at 60° C. After being cooled, the reaction mixture was filtered through cerite, and the filtrate was concentrated in vacuo. The residue was purified by means of column chromatography (silica gel, 1:19 methanol:chloroform) to give 210 mg (0.51 mmol) of the title compound.

Provenance & Evidence