Sodium borohydride → HCID 11695520, compound

Participants

Reaction Steps

To a solution of 240 mg (0.54 mmol) of 3-[2(diethylamino)ethyl]-4-phenyl-4-trichloromethyl-2-oxo -1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine in 10 mL of dimethylformamide was added 82 mg (1.26 mmol) of sodium borohydride at temperature of 5° C. to 15° C. After being stirred for 3 hours at ambient temperature, the reaction mixture was poured onto ice water, and the mixture was extracted with ethyl acetate. The organic layer separated was washed with water and then with brine, dried on anhydrous sodium sulfate and then concentrated in vacuo. The residue was purified by means of column chromatography (silica gel, 1:9 methanol:chloroform) to give 110 mg (0.34 mmol) of the title compound.

Provenance & Evidence