HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Ethylaniline → 3-Butyryl-4-(2-ethylphenylamino)-8-(2-methylthioethoxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Ethylaniline | HCID 11357 | — |
| Reactant | 3-Butyryl-4-chloro-8-(2-methylthioethoxy)quinoline | HCID 54562429 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-Butyryl-4-(2-ethylphenylamino)-8-(2-methylthioethoxy)quinoline | HCID 54256513 | 69.4% |
Reaction Steps
A mixture of 3-butyryl-4-chloro-8-(2-methylthioethoxy)quinoline (3.69 g, 9.84 mmol) and 2-ethylaniline (1.55 g, 12.8 mmol) in acetonitrile (20 ml) was refluxed for 6 h. The solution was evaporated. Chromatography (SiO2 ; CH2Cl2 : MeOH 97:3) gave 2.79 g (69%) of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05556863 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-f01771f088084703b5bf1b2a9bed3f3a |
| Source note | uspto-grants-1996_09 |