4-Methylmorpholine → Z-Phe-D-Trp-OMe

참여 물질

역할	이름	HCID	투입량
반응물	4-Methylmorpholine	HCID 7972	—
반응물	1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide	HCID 15908	—
반응물	Benzyloxycarbonyl-L-phenylalanine	HCID 70878	—
반응물	1-Hydroxybenzotriazole	HCID 75771	—
반응물	methyl (2R)-2-amino-3-(1H-indol-3-yl)propanoate hydrochloride	HCID 11448200	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	Z-Phe-D-Trp-OMe	HCID 15755276	48%

반응 단계

0.60 g (2 mmol) of Z-Phe-OH, 0.51 g (2 mmol) of H-D-Trp-OMe.HCl, 0.46 g (2.4 mmol) of EDCI, 0.32 g (2.4 mmol) of HOBT and 0.44 ml (4 mmol) of NMM are dissolved at -10° C. in 10 ml THF and stirred at room temperature for 15 hours. The THF is distilled off under vacuum, the residue dissolved in 50 ml ethyl acetate and the organic phase washed three times with 10 ml 0.5 N HCl, 10% NaHCO3 solution and water respectively. The organic phase is dried with MgSO4 and the solvent distilled off under vacuum. 0.48 g (48%) of thin-layer chromatographically identical Z-Phe-D-Trp-OMe are obtained as a colourless powder.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05556836
출처 데이터셋	uspto-grants-1996_09
ORD ID	ord-b124a6c7295e4cb596a9cfda04a9d825
출처 메모	uspto-grants-1996_09