Potassium Carbonate → HCID 19424222, compound

Participants

Reaction Steps

Hydrolysis of 57 (0.28 g) with K2CO3 in MeOH/water at 50° C. for 5 hours, under nitrogen as above, gave an oil. Chromatography on silica gel, eluting with EtOAc:light petroleum (1:1) containing 1% AcOH, gave 2,2'-dithiobis[N-(4-carboxy-3-hydroxybenzyl)-3-(3-indolyl)propanamide] (58) [VI: n=2; R1 =R3 =H, R2 =(CH2)2CONHCH2Ph{3-OH, 4-COOH}] (72 mg, 27% mp (MeOH/dilute HCl) 160°-163.5° C. (dec).

Provenance & Evidence