反应详情

To a solution of 5-(5-chlorobenzoxazol-2-yl)-2-n-propylaminoaniline (see Working Example 135-1) (200 mg, 0.663 mmol) in ethanol (5 mL) was added methyl acetimidate hydrochloride (123 mg, 0.995 mmol), and this was heated to reflux for 5 hours. After the reaction was complete, saturated aqueous sodium hydrogen carbonate solution was added, and this was extracted with chloroform. The organic layer obtained was dried over anhydrous sodium sulfate, filtered, and concentrated to give crude crystals that were washed with diethyl ether to yield the title compound (155 mg, 72% yield) as green crystals.

1. temperaturethis was heated
2. temperatureto reflux for 5 hours
3. extractionthis was extracted with chloroform
4. customThe organic layer obtained
5. dry with materialwas dried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customto give crude crystals that
9. washwere washed with diethyl ether