Hydrochloric Acid → 1-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine hydrochloride

HRID 743179ノート

反応式

HRID 743179 の反応式
[ClH:1].[CH3:2][N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O1CCOCC1.C(OCC)(=O)C>[ClH:1].[CH3:2][N:3]1[CH2:7][CH2:6][CH2:5][CH:4]1[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH2:17][CH2:18][CH2:19][CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 106907751-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine

生成物 1

HCID 194239751-Methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine hydrochloride

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 312751,4-Dioxane溶媒

実験手順

0.2 ml of a 4N solution of hydrogen chloride in dioxane was added to a solution of 130 mg of 1-methyl-2-{2-[2-(4-phenylbutyl)phenoxy]ethyl}pyrrolidine [prepared as described in step (a) above] in 5 ml of ethyl acetate, and the resulting mixture was worked up in a similar manner to the procedure described in Example 1(c). The solvent was removed by distillation under reduced pressure, and the residue was dried in vacuo, to give 144 mg of the title compound as a colorless oil.

後処理

  1. customThe solvent was removed by distillation under reduced pressure
  2. customthe residue was dried in vacuo

出典と根拠

ORDレコード
ord-f466fb14676e4f0598b0488db598de97
出典データセット
uspto-grants-1996_09
特許番号
US05556864

反応ノート

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