反应详情

温度

100 °C

To a solution of 5-chloro-2-(2-(3,3,3-trifluoropropyl)aminoanilin-5-yl)benzoxazole (see Working Example 138-1) (200 mg, 0.562 mmol) in triethyl orthoformate (5 mL) was added p-toluenesulfonic acid (10 mg), and this was stirred at 100° C. for 4 hours. After the reaction was complete, saturated aqueous sodium hydrogen carbonate solution was added, and this was extracted with chloroform. The organic layer obtained was dried over anhydrous sodium sulfate, filtered, and concentrated to give crude crystals that were washed with diethyl ether and ethyl acetate to yield the title compound (127 mg, 62% yield) as light yellow crystals.

1. extractionthis was extracted with chloroform
2. customThe organic layer obtained
3. dry with materialwas dried over anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customto give crude crystals that
7. washwere washed with diethyl ether and ethyl acetate