Dimethylamine → HCID 19423959, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 1(b), 291 mg of 2-{2-[4-(2-naphthyl)butyl]phenoxymethyl}oxirane [prepared as described in step (a) above] dissolved in 5 ml of tetrahydrofuran were treated with 1 ml of 50% by volume aqueous dimethylamine. The crude product thus obtained was purified by column chromatography through silica gel, using a 10:1 by volume mixture of methylene chloride and methanol as the eluent, to give 279 mg (yield 84%) of the title compound.

Provenance & Evidence