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Triphenylphosphine → HCID 10836736、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triphenylphosphine | HCID 11776 | — |
| 反応物 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 反応物 | Tert-butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate | HCID 5103438 | — |
| 反応物 | 2-(4-Phenylbutyl)phenol | HCID 12596489 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 10836736 | HCID 10836736 | 34.6% |
反応手順
Following a procedure similar to that described in Example 5(a), 1.69 g of 2-(4-phenylbutyl)phenol (prepared as described in Preparation 3), 1.72 g of 1-t-butoxycarbonyl-2-(2-hydroxyethyl)piperidine, 5.9 g of triphenylphosphine and 3.92 g of diethyl azodicarboxylate were reacted in 75 ml of methylene chloride. The crude oily product, extracted as described in Example 5(a), was purified by column chromatography through silica gel, using a 5:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 1.13 g (yield 34%) of the title compound as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05556864 |
| 出典データセット | uspto-grants-1996_09 |
| ORD ID | ord-4079b2cba14c4eff88d617befb2759a7 |
| 出典メモ | uspto-grants-1996_09 |