Hydrochloric Acid → HCID 67667820, compound

Participants

Reaction Steps

3 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 173 mg of (4R)-1-t-butoxycarbonyl-4-hydroxy-2-[2-(4-phenylbutyl)phenoxymethyl]pyrrolidine [prepared as described in step (b) above] in 3 ml of dioxane, and the resulting mixture was allowed to stand at room temperature for 2 hours. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure, and the residue was dissolved in methylene chloride. Ethyl acetate was added to the resulting solution and the mixture was allowed to stand. The crystals which precipitated were collected by filtration, to give mg (yield 74%) of the title compound as colorless crystals, melting at 135°-137° C.

Provenance & Evidence