反应详情

379 mg of 1-t-butoxycarbonyl-4-{2-[2-(3-methoxyphenyl) ethyl]phenoxy}piperidine [prepared as described in step (a) above] were dissolved in 5 ml of a 4N solution of hydrogen chloride in dioxane, and the solution was allowed to stand at room temperature for 1 hour. The reaction mixture was then concentrated by distillation under reduced pressure, and the resulting oily residue was dissolved in 10 ml of ethyl acetate, after which it was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 290 mg (yield 90%) of the title compound as colorless crystals, melting at 121°-122° C.

1. concentrationThe reaction mixture was then concentrated by distillation under reduced pressure
2. dissolutionthe resulting oily residue was dissolved in 10 ml of ethyl acetate
3. customto stand at room temperature
4. customThe crystals which precipitated
5. filtrationwere collected by filtration
6. customdried in vacuo