Aluminium lithium hydride → HCID 22865497, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 38(a), 1.50 g of (S)-4-t-butoxycarbonyl-2-{2-[2-(3-methoxyphenyl)ethyl]phenoxymethyl}morpholine [prepared as described in Example 71(a)] were reacted with 167 mg of lithium aluminum hydride dispersed in 20 ml of tetrahydrofuran. The mixture was then worked up as described in Example 38(a), and the crude product thus obtained was purified by column chromatography through silica gel, using a 20:1 by volume mixture of methylene chloride and methanol as the eluent, to give 1.04 g (yield 87%) of the title compound as a colorless oil.

Provenance & Evidence