Hydrochloric Acid → HCID 67669462, compound

Participants

Reaction Steps

5 ml of a 4N solution of hydrogen chloride in dioxane were added to a solution of 630 mg of (R)-1-t-butoxycarbonyl-2-[2-(2-phenylethyl)phenoxymethyl]pyrrolidine [prepared as described in step (a) above] in 5 ml of dioxane, and the resulting mixture was allowed to stand at room temperature for 1 hour. At the end of this time, the solvent was removed by distillation under reduced pressure, and the resulting oily residue was cooled, which resulted in its solidification. The solid was triturated in pentane, and the resulting powder was collected by filtration to give 360 mg (yield 68%) of the title compound as a colorless solid, melting 73°-88° C. [α]D25 -7.5° (c=3.76, ethanol).

Provenance & Evidence