Hydrochloric Acid → HCID 19423850, compound

Participants

Reaction Steps

400 mg of 1-t-butoxycarbonyl-2-(2-{2-[4-(3-methoxyphenyl)butyl]phenoxy}ethyl)piperidine [prepared as described in step (a) above] were dissolved in 2 ml of dioxane, and 2 ml of a 4N solution of hydrogen chloride in dioxane were added to the solution, which was then allowed to stand at room temperature for 30 minutes. At the end of this time, the solution was concentrated by distillation under reduced pressure, and the resulting oil was dissolved in diethyl ether and allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 276 mg (yield 80%) of the title compound as a colorless solid, melting at 76°-79° C.

Provenance & Evidence