Hydrochloric Acid → HCID 57497652, compound

Participants

Reaction Steps

0.410 g of 2-(2-{2-[2-(2-chlorophenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine [prepared as described in step (a) above] was dissolved in 5 ml of methylene chloride, and 0.35 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The resulting mixture was concentrated by distillation under reduced pressure. The resulting solid was dissolved in a small amount of methylene chloride, and 30 ml of ethyl acetate was added to the solution, which was then allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.408 g (yield 90%) of the title compound as colorless crystals, melting at 187°-188° C.

Provenance & Evidence