HCID 10523802, compound → HCID 57497653, compound

Participants

Reaction Steps

0.450 g of 2-(2-{2-[2-(4-chlorophenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine [prepared as described in step (a) above] was dissolved in a small amount of dioxane, and 0.36 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The mixture was then concentrated by distillation under reduced pressure. The concentrate was dissolved in 15 ml of ethyl acetate and allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.350 g (yield 70%) of the title compound as colorless crystals, melting at 145°-146° C.

Provenance & Evidence