Hydrochloric Acid → HCID 67668836, compound

Participants

Reaction Steps

0.500 g of (S)-4-t-butoxycarbonyl-2-[2-(2-phenylethyl)phenoxymethyl]morpholine [prepared as described in step (a) above] was dissolved in 2 ml of dioxane, and 4 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then allowed to stand at room temperature for 1 hour. At the end of this time, the mixture was concentrated by distillation under reduced pressure. The resulting oil was dissolved in 15 ml of ethyl acetate and allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.345 g (yield 82%) of the title compound as colorless crystals, melting at 143°-145° C.

Provenance & Evidence