Hydrochloric Acid → HCID 67668991, compound

Participants

Reaction Steps

0.560 g of (S)-4-methyl-2-[2-(2-phenylethyl)phenoxymethyl]morpholine [prepared as described in step (a) above] was dissolved in 5 ml of dioxane, and 0.56 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution. The mixture was then concentrated by distillation under reduced pressure, and the resulting oil was dissolved in 10 ml of ethyl acetate and allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.448 g (yield 72%) of the title compound as colorless crystals, melting at 125°-127° C.

Provenance & Evidence