Hydrochloric Acid → HCID 57497660, compound

Participants

Reaction Steps

0.690 g of (S)-2-(2-{2-[2-(3-difluoromethoxyphenyl)ethyl]phenoxy}ethyl)-1-methylpyrrolidine [prepared as described in step (b) above] was dissolved in 5 ml of dioxane, and 0.55 ml of a 4N solution of hydrogen chloride in dioxane was added to the solution, which was then concentrated by distillation under reduced pressure. The resulting oil was dissolved in 15 ml of ethyl acetate, and the solution was allowed to stand at room temperature. The crystals which precipitated were collected by filtration and dried in vacuo, to give 0.375 g (yield 50%) of the title compound as colorless crystals, melting at 119°-120° C.

Provenance & Evidence