HCID 10697569, compound → HCID 10836976, compound

Participants

Reaction Steps

A solution of 0.951 g of (2R,4R)-4-benzyloxy-1-ethoxycarbonyl-2-(2-{2-[2-(3,5-dimethoxyphenyl)ethyl]phenoxy}ethyl)pyrrolidine and 95 m g of 5% w/w palladium-on-carbon in 6 ml of ethanol was stirred under an atmosphere of hydrogen at 60° C. for 9 hours. At the end of this time, the mixture was cooled, and the catalyst was removed by filtration. The filtrate was then concentrated by distillation under reduced pressure. The resulting oil was purified by column chromatography through silica gel, using a 1:2 by volume mixture of hexane and ethyl acetate as the eluent, to give 0.717 g (yield 91%) of (2R,4R)-1-ethoxycarbonyl-4-hydroxy-2-(2-{2-[2-(3,5-dimethoxyphenyl)ethyl]phenoxy}ethyl)pyrrolidine as a colorless oil.

Provenance & Evidence